Although the majority of hereditary thrombophilic factors that have emerged involve coagulation factors, such as Leiden factor V G1691A and the prothrombin G20210A mutation [8-10], we have previously reported on the role of platelet-derived thrombophilia in spontaneous miscarriages, and in particular, we found that the genetic polymorphisms of the platelet glycoproteins Ia (GpIa-C807T) and IIIa (GpIIIa-T1565C-PlA1/PlA2) are associated with increased risk of spontaneous recurrent miscarriages. This evidence concerns the gene ITGB3 and thrombophilia.