In obese individuals, hypermethylation of POMC has been observed whereas NPY tends to be hypomethylated [17]. Since DNA methylation is most associated with gene silencing, it stands to reason that a cause-and-effect relationship potentially exists between obesity and excessive silencing of the satiety gene and/or insufficient silencing of the hunger gene. These findings further support the existence of a relationship between the obesity phenotype and the methylation status of genes that control the body’s desire for food and, therefore, food intake. This evidence concerns the gene NPY and obesity disorder.