INS and diabetes mellitus: However, aberrant hormone secretion may give rise to various diseases and disorders.[69, 70] In the case of insulin, deficiency in its secretion could bring about diabetes and hyperglycemia, while excessive insulin can result in hypoglycemia.[71] For patients with type 1 diabetes, pancreatic islet or whole pancreas transplantation is the most promising treatment currently available to restore β‐cell mass and maintain normoglycemia while simultaneously ameliorating hypoglycemia.