Despite the great worldwide interest in the knowledge of the adaptive changes to hypoxia in areas such as sport and the knowledge of the physiological effects of altitude on the transcription of HIF-1α and its role in the adaptation to chronic hypoxemia of chronic noncommunicable diseases [2], it is not yet known what is the effect of physical exercise on the adaptive molecular changes to hypoxia in people with COPD living at high altitude and how these adaptations would improve physical performance and fatigue tolerance. Here, HIF1A is linked to chronic obstructive pulmonary disease.