The comparison between the active (including moderate and high activity groups) and inactive (low activity and remission groups) RA groups indicated that the mRNA levels of NLRP3 and caspase-1 in both the inactive and active groups were higher than those in the HC group, but there were no notable differences between the inactive and active groups (Fig. 2B, C). Here, CASP1 is linked to rheumatoid arthritis.