To explore the relationships among the mRNA expression levels of these inflammasomes, plasma IL-1beta, IL-18 levels and clinical characteristics of RA patients, multiple linear regression analysis was used to analyze the relative mRNA expression levels of NLRP1, NLRP2, NLRP3, NLRC4, NLRC5, NLRP12, AIM2, CARD8, IFI16, Pyrin, NAIP, Caspase-1, Caspase-4, Caspase-5, IL-1beta, IL-18 mRNA and plasma IL-1beta and IL-18 levels and the clinical characteristics of RF, anti-CCP, CRP and ESR. This evidence concerns the gene CARD8 and rheumatoid arthritis.