Additionally, many researchers also designed corresponding nano-biomaterials to enhance the immune effect of radiotherapy based on express high levels of nutrients depleting related ectoenzymes (e.g., indoleamine 2,3-dioxygenase 1 (IDO-1) [61–64] in TME, and some reports focused on the physical tumor microenvironment [65]. This evidence concerns the gene IDO1 and neoplasm.