Five MDSC markers (ITGAM, LOX, S100A9, CD80, and CD83) correlated well with SF3B4 expression, and these six gene signatures (SF3B4 and five MDSC markers) were significantly associated with HCC differentiation and patient prognoses in terms of OS, DFS, DSS, and PFS. The gene discussed is CD80; the disease is hepatocellular carcinoma.