NR3C1 and major depressive disorder: Among the annotated sites of differential methylation, we noted methylation within the RES cohort at NR3C1. NR3C1 is a glucocorticoid receptor gene, which has been associated with increased methylation in other studies of perinatal stress to newborns [53, 54], as well as trauma [55], psychological disorders, including major depression, post-traumatic stress disorder, anxiety, and personality disorders [56].