The research revealed that RAI2 was down-regulated in most tumors, including bladder urothelial carcinoma (BLCA), stomach adenocarcinoma (STAD), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma (HNSC), prostate adenocarcinoma (PRAD), among others (Figure 2A). The gene discussed is RAI2; the disease is invasive breast carcinoma.