Additionally, PCMT1 inhibition promoted the expression of Bax (a pro-apoptotic molecule) and cleaved caspase-3 (the most important terminal splicing enzyme in the process of apoptosis), and suppressed Bcl-2 (an anti-apoptotic molecule) expression (Figure 5B), thereby promoting the apoptosis of PCa cells. The gene discussed is BAX; the disease is posterior cortical atrophy.