TNC and neoplasm: The most highly upregulated proteins with advanced reproductive age included immunoglobulins, ECM proteins such as tenascin-C, tenascin-X, and TGFβ-induced protein, proteins that regulate metal homeostasis such as ferritin and ceruloplasmin, as well as tumor suppressors such as SDH enzyme and glycoprotein NMB (Figure 5C, 5D).