NEFL and Alzheimer disease: Of all the examined plasma biomarkers, plasma NfL showed the highest AUC value for differentiating between AD and the combined non-dementia groups (i.e., MCI plus normal cognition) (AUC = 0.73; 95% CI 0.69–0.77; Fig. 4A), between AD and normal cognition (0.75; 0.70–0.79; Fig. 4B), and between AD and MCI (0.69; 0.64–0.74; Fig. 4D).