A2AR modulate key astrocytic functions that are affected by Aβ exposure, such as glutamate uptake [21], ATP release and hemichannel activity [20], and Ca2+ signalling [22], and we recently showed that the genetic deletion of astrocytic A2AR in the hippocampus of adult mice impairs synaptic plasticity and cause memory deficits [23]. The gene discussed is ADORA2A; the disease is memory.