Likewise, as occurs for Cx43, astrocytic A2AR are increased in the hippocampus of mice exposed intra-cerebro-ventricularly to Aβ [21], mice expressing human amyloid precursor protein [29], 3xTg-AD mice [28] and APP/PS1 mice [26] as well as in AD patients [29]. The gene discussed is APP; the disease is Alzheimer disease.