Although, we had previously shown that A2AR control Cx43 hemichannels in cultured astrocytes exposed to Aβ peptides [20], we now extend our studies to a more complex system, namely mouse hippocampal slices modelling early or advanced stages of AD, in which A2AR were genetically silenced in astrocytes and/or in neurons. This evidence concerns the gene GJA1 and Alzheimer disease.