In early AD modelled by Aβ-icv exposure, there was an increase in Cx43 phosphorylation at Ser368 without alterations of the total levels of Cx43, whereas in hippocampal gliosomes of 9-month-old APP/PS1 mice already displaying sparse Aβ plaques, there was an increase in Cx43 levels without alterations in Cx43 phosphorylation at Ser368. Here, APP is linked to Alzheimer disease.