In fact, whereas A2AR are canonically coupled to the activation of adenylate cyclase and generation of cAMP [46], these pleiotropic receptors seem to be mostly coupled to PKC when they are upregulated in disease conditions associated with increased glutamatergic signalling [74], such as in early AD (see e.g. [75–77]). The gene discussed is PRRT2; the disease is Alzheimer disease.