This finding is aligned with previous observations that an increase in astrocyte reactivity is linked to the accumulation of Aβ associated with AD, as assessed by the analysis of GFAP immunoreactivity in human samples and animal models of AD [6, 27, 49, 50], namely in APP/PS1 mice [7, 14, 51, 52]. Here, GFAP is linked to Alzheimer disease.