AD is characterised by 1) the presence of amyloid-β plaques, 2) the formation and deposition of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau proteins, 3) oxidative stress, 4) neuronal death starting from the hippocampus, 5) astrocytosis and microgliosis 6) neuroinflammation, and 7) NLRP3 inflammasome activation; all of which lead to progressive memory loss and eventually dementia [7, 9-10]. Here, MAPT is linked to Alzheimer disease.