TNF and Alzheimer disease: Single nucleotide polymorphisms (SNP) of both pro- and antiinflammatory cytokines, IL-1, IL-6, TNFα, IL-4, IL-10, TGFβ [14], and its promoters, IL-1α -889, IL-6 -176, IL-8 -251, IL-10-1082, IL-10 -819, and IL-18 -607 have been reported in AD [14, 15] and PD [15] suggesting a link with immune response.