Among the filtered cilium assembly genes, including ift57, ift172, dzip1l and ofd1, we focused on ofd1 gene with 0.59 at log2-fold changes as a target of ik, because the previously known physiological phenotypes of ofd1 mutants were considerably similar to ik mutants showing ciliopathy such as body curve, otolith abnormalities and a wide spectrum of malformations [31]. The gene discussed is IFT57; the disease is ciliopathy.