Univariate and multivariate Cox regression analyses were used to explore whether the above seven plasma biomarkers are independent prognostic factors for UTUC. According to univariate Cox regression analysis, we found that Fib, GGT, CRE, BUN, LDH, and ALB correlated significantly with overall survival (OS) (all p < 0.05) (Fig. 1a). Multivariate Cox regression analysis indicated that Fib, GGT, CRE, LDH, and ALB were associated with OS (Fig. 1b). The gene discussed is ALB; the disease is renal pelvis/ureter urothelial carcinoma.