However, the IgM-rich IVIG group showed a positive effect in the treatment of neonatal sepsis (Fig. 6): RR 0.45, 95% CI: 0.25–0.80; heterogeneity χ2 = 6.13, df = 4, p = 0.19, I2 = 35%. This evidence concerns the gene CD40LG and Neonatal sepsis.