Besides, the results showed that IgM-rich IVIG was effective in treating sepsis (Fig. 4): RR 0.55, 95% CI: 0.40–0.76; heterogeneity χ2 = 10.75, df = 11, p = 0.46, I2 = 0%, while standard IVIG failed to be effective (Fig. 4): RR 0.91, 95% CI: 0.81–1.02; heterogeneity χ2 = 28.48, df = 17, p = 0.04, I2 = 40%. This evidence concerns the gene CD40LG and Sepsis.