VAMP2 and Alzheimer disease: In a previous study comparing the expression of seven presynaptic proteins in postmortem tissue, VAMP-2 was the only protein decreased in all tested brain regions (CA1 region in the hippocampus, the occipital cortex, the entorhinal cortex and caudate nucleus) of AD compared to non-neurodegenerative controls and low VAMP-2 expression was associated with MMSE and FCSRT scores in the hippocampus and entorhinal cortex [40].