In the tumor, a considerable increase of TRM phenotype was observed only in CD28− T lymphocytes (percentage of TRM within PD1+CD28− T cells, NT vs T, P = 0.01), strongly indicating that most PD1+CD28− T cells infiltrating the NSCLC tumor site possess a TRM phenotype, as previously reported [34, 36]. The gene discussed is PDCD1; the disease is non-small cell lung carcinoma.