KLRC1+KLRK1+TRMCD28− cluster did not show significantly up-regulated cytotoxic-related genes, rather BTG1, homeostatic IL7R, IL2RB and IL2RA. TRM determinant CD103 was also found in cluster4 of CD28− T cells, poorly represented within peripheral blood and at the NT tissue, while abundant at the tumor site. The gene discussed is KLRK1; the disease is neoplasm.