CD28 and non-small cell lung carcinoma: The analysis of the T-cell differentiation stage by CCR7 and CD45RA expression in CD8+PD1+CD28− T cells isolated from peripheral blood of NSCLC patients, showed a predominant terminal-differentiated effector-memory (EMRA, 65.4%) and effector-memory (EM, 27.3%) phenotype (Fig. 2C,D).