We next focused on cluster4 Treg-like TRM CD28− (Fig. 7D,F and Table S4), due to its potential critical role and its exclusively relevant expression in the tumor, and found a 6 genes signature (C4 Treg-like TRM CD28−/ Adaptive Immunity: CD74, LAG3, CD8B, HLA-DMA, HLA-DRA, HLA-DPA1). Here, LAG3 is linked to neoplasm.