Cluster3 of both subsets (which we refer to as NK-innate-likeCD28− and CD28+, respectively), represented in peripheral blood and reduced at the tumor site, were characterized by the expression of NK-like markers KLRB1, KLRC3, and KIR2DL1, along with IKZF2 and ZBTB16 (PLZF). This evidence concerns the gene CD28 and neoplasm.