Differently, differences between the two subsets were clearly less evident at the NT and even not significant in the tumor site, either in terms of IFN-ɣ, TNF-α and polyfunctionality, with a partial functional advantage of PD1+CD28− T cells only in terms of GrzB (P < 0.003) (Fig. 3G). The gene discussed is IFNA1; the disease is neoplasm.