Suzuki et al.6 revealed that mutations in U1 in SHH medulloblastoma can notably suppress the tumor suppressor gene patched 1 (PTCH1) and activate oncogenes GLI family zinc finger 2 (GLI2) and cyclin D2 (CCND2), suggesting that U1 may serve as a therapeutic target for this tumor. The gene discussed is CCND2; the disease is medulloblastoma.