The relationship between thyroid function and depression has been of great interest to scholars, and it has been suggested that there are alterations in the function of the hypothalamic pituitary thyroid (HPT) axis in patients with depression, and it has been reported that disturbances in the level of thyroid hormones not only affects the patient's emotional response, but also serves as a marker of sensitivity in some patients with depression15. This evidence concerns the gene TG and major depressive disorder.