CGAS and neoplasm: Here, we hypothesized that the hDT806-induced DNA damage may activate the cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP) synthase (cGAS)/STING pathway, which is known to be triggered by cytosolic DNA, either exogenous or endogenous, and has been established as a critical activator of anti-tumor immune responses36.