Since hDT806 treatment increased the proteins of the STING-IFN-I axis in the JHU-029 HNSCC cells as well as xenograft tumors, we overexpressed ectopic STING protein in JHU-029 to confirm that upregulated STING expression indeed leads to the activation of IFN-I in the HNSCC cells. The gene discussed is STING1; the disease is head and neck squamous cell carcinoma.