IGF2BP3 and neoplasm: Given the facts that circITGB6 promotes EMT process and cell migration through its association with IGF2BP3 (Fig. 4g, h), with limited effect on IGF2BP3 abundance (Figs. 4g, 5h and Supplementary Fig. 5), we wondered if circITGB6 promotes tumor metastasis through modulating certain mRNA cargos of IGF2BP3.