Here, we identified IGF2BP3 as a TGFβ-responsive circITGB6 interactor (Fig. 4a–f), whose depletion abolished the metastasis-promoting effect of circITGB6 (Fig. 4 g, h), consistent with the positive correlation between IGF2BP3 and tumor metastasis43,61. Here, IGF2BP3 is linked to neoplasm.