In accordance to the aforementioned implication of circITGB6 in TGFβ signaling, circITGB6 overexpression significantly promoted cell migration in lung cancer A549, breast cancer MCF7 and CRC SW620 cells (Fig. 2b), while knockdown of circITGB6 dramatically weakened cell migration in lung cancer HCC827 and pancreatic cancer Capan-2 cells (Fig. 2c), with limited effect on cell proliferation (Supplementary Fig. 3g, h). This evidence concerns the gene TGFB1 and breast cancer.