To further confirm the positive correction between circITGB6 and PDPN, we examined circITGB6 abundance by RNAscope assay and PDPN expression by Immunohistochemistry (IHC) assay in the primary tumor and metastatic liver lesions of mice intrasplenically injected with SW620 cells (mentioned in Fig. 5i). The gene discussed is PDPN; the disease is neoplasm.