Moreover, the activated circITGB6/IGF2BP3/PDPN axis is closely correlated to metastasis status in lung cancer patients (Fig. 7c, d), increased lymph node metastasis (Fig. 7a, b) as well as worse prognosis in CRC patients (Fig. 1m), reinforcing the critical role of circITGB6 in tumor metastasis. This evidence concerns the gene PDPN and neoplasm.