IGF2BP3 and neoplasm: To figure out whether direct interaction of circITGB6 with IGF2BP3 contributes to the metastatic effect of circITGB6, A549 and SW620 cells with enforced expression of circITGB6-WT or equivalent circITGB6-mut variants were employed to evaluate their cell migration and tumor metastasis abilities (Supplementary Fig. 6a).