TGFβ plays a critical role in tumor metastasis25, the implication of circITGB6 in TGFβ signaling (Fig. 1a–d and Supplementary Figs. 1a–f, 2i) as well as tumorigenesis (Supplementary Fig. 2c) prompted us to investigate the correlation between circITGB6 and tumor metastasis. This evidence concerns the gene TGFB1 and neoplasm.