In addition, loss of Cited1 expression accompanied with an increase in the EMT hallmark Fibronectin 1 and the antithetic expression between AXL and MITF that we found in the TG2 KO model, collectively support the idea of a possible participation of TG2 in the modulation of melanoma heterogeneity via the phenotype switching. The gene discussed is AXL; the disease is melanoma.