MITF and melanoma: Consistent with the downregulation of melanogenesis-related genes, ablation of TG2 leads to a reduction of MITF mRNA levels, both in B16F10 melanoma TG2 KO clones (Fig. 5a), as well as in human melanoma cell lines Mel JuSo, IPC-298 and SK-MEL-3 following downregulation of TG2 by siRNA (Fig. 5b).