Lewy bodies (LB) are intraneuronal inclusions largely composed of α-Synuclein (αSyn) and are found in Lewy body diseases (LBD), a family that encompasses Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and Alzheimer’s disease (AD) with LB co-pathology1,2. The gene discussed is SNCA; the disease is Alzheimer disease.