Independent molecular profiling confirmed the two populations had distinct mutational profiles with the T cell population harboring IDH2, RHOA, DNMT3A, and TET2 mutations24,25, typical of AITL, while the plasma cells harbored BRCA2, BTG, EPHA5, KMT2D, and SETD5 mutations (Fig. 3a). The gene discussed is SETD5; the disease is angioimmunoblastic T-cell lymphoma.