While mutations in certain genes, such as BRAF, CALR, JAK2 and MPL, have diagnostic utility in myeloid neoplasms, for example, others such as CEBPA, DNMT3A, FLT3, IDH1, IDH2, KIT, NPM1, and TP53 have prognostic and/or therapeutic implications, particularly when determining whether a patient should undergo an allogeneic stem cell transplant1,2. The gene discussed is DNMT3A; the disease is myeloid neoplasm.