While DNMT3A and TET2 mutations have been reported to reside in both AITL and clonally related CH26, which may account for the detection of these alterations in both the enriched T-cell and unsorted samples27,28, the ability to sort and enrich samples is a powerful tool to interrogate mixed hematopoietic samples to assess clonal relatedness and understand the underlying biology of each population. This evidence concerns the gene TET2 and angioimmunoblastic T-cell lymphoma.