In particular, within FL and DLBCL, the following genes were frequently affected by two hits via mutation and LOH: TNFRSF14 (n = 76), CREBBP (n = 71), TNFAIP3 (n = 30), and B2M (n = 29). The gene discussed is TNFAIP3; the disease is diffuse large B-cell lymphoma.