BRCA2 and angioimmunoblastic T-cell lymphoma: Independent molecular profiling confirmed the two populations had distinct mutational profiles with the T cell population harboring IDH2, RHOA, DNMT3A, and TET2 mutations24,25, typical of AITL, while the plasma cells harbored BRCA2, BTG, EPHA5, KMT2D, and SETD5 mutations (Fig. 3a).