Our finding concerning the co-dependence of medulloblastoma cells on BCL-XL and MCL-1 is supported by previous studies highlighting that cellular apoptotic sensitivity and anti-apoptotic dependence is linked with the tissue of origin [71], and as medulloblastoma cells resemble cerebellar precursor cells [72] which are also BCL-XL and MCL-1 co-dependent [73], this finding may be somewhat expected. This evidence concerns the gene BCL2L1 and medulloblastoma.