Given that we observe increased expression of Il13ra1 in FACs-isolated tuft cells compared to other cells of the gastric epithelium in tumor of gp130F/F mice, we speculate that tuft cell expansion that occurs during metaplasia and adenoma formation, is driven by both inflammation-associated effectors cells as well as an autocrine/paracrine loop across the epithelium. The gene discussed is IL13RA1; the disease is neoplasm.