From this data, we surmise that tuft cell-derived IL25, and ILC2-produced IL13 support gastric tumor progression through the establishment of a feed-forward circuit comprising epithelial tuft cell in the tumor and hematopoietic ILC2s in the tumor microenvironment to collectively sustains epithelial proliferation and survival of gastric tumor cells. This evidence concerns the gene IL13 and gastric neoplasm.