LIN28B and neoplasm: Similar data were seen in human PDAC, as CM from PANC-1, PANC03.27 and hPDAC1# induced LIN28B expression in human CAFs (hCAFs) in a LIN28B-‍dependent manner (Fig. 2p–r and Supplementary Fig. 1f–h), confirming that loss of Lin28b in tumor epithelium leads to the inactivation of Lin28b in CAFs in both human and murine PDAC.