Specifically, candidate gene analyses demonstrated that single nucleotide polymorphisms (SNPs) in the OAS2, OAS3, CD209, TLR3, IL28B, MMP9, and IL10 genes, which encode key components of the innate immune response, are associated with predisposition to TBE in Russian residents from Novosibirsk and Irkutsk (Barkhash et al. 2016, 2018a, b; 2012, 2010, 2013). Here, MMP9 is linked to tick-borne encephalitis.