GHRL and Anxiety: In many cases the actions of ghrelin phenocopy those of AgRP neurons; 1) ghrelin is a bona fide hunger signal as it elicits an operant behavioural response learned during hunger (fasting) [10,30]; 2) ghrelin increases food intake, motivation and dopamine neural circuits [16,[31], [32], [33]]; 3) ghrelin supresses energy expenditure and lipid utilisation [34,35]; and 4) ghrelin reduces anxiety-like behaviour and increases exploratory behaviour [[36], [37], [38]].