TGFB1 and Hepatic fibrosis: Importantly, hepatic delivery of siRNAs specifically targeting TET3 using adeno-associated viruses serotype 8 (AAV8) ameliorated fibrosis in a mouse model of carbon tetrachloride (CCl4)-induced liver fibrosis, demonstrating the TET3/TGF-β positive feedback loop as a crucial mechanism of liver fibrosis [9].