Lymphocyte function-associated antigen-1 (LFA-1), composed of αL and β2 subunits, also proved to bind to GAL-8 in a carbohydrate-dependent manner, and this interaction was displaced by anti-GAL-8 autoantibodies isolated from patients with systemic lupus erythematosus (SLE). Here, LGALS8 is linked to systemic lupus erythematosus.