When plates pre-coated with GAL-4 were sequentially incubated with different CEA concentrations, LS174T cell binding to this lectin was inhibited, suggesting that robust interactions between GAL-4 with both SB1a and CEA are required to promote colon adenocarcinoma cell adhesion (163).These results underlie the relevance of galectins-CEA interactions in promoting colon cancer metastasis. Here, LGALS4 is linked to colonic neoplasm.