LGALS3 and breast carcinoma: By using GPVI-conjugated fluorescent microspheres and static adhesion assays in CRISPR/Cas9-GAL-3-deficient colon (MC38) and breast cancer (AT-3, 4T1, and E0771) cells, the collagen-like domain was found to be essential in GAL-3-GPVI interactions (148) (Table 2).