Particularly, recombinant GAL-3, at concentrations similar to those found in the circulation of patients with metastatic cancer, significantly increased the adhesion of breast and colon cancer cells to the endothelium as a consequence of its interaction with TF expressed on MUC1, causing a redistribution of this glycoprotein on the cancer cell surface (125). This evidence concerns the gene LGALS3 and colonic neoplasm.