In addition, given that GAL-1 activates VEGFR-2 and NRP-1 signaling and modulates the migration of vascular endothelial cells (37) and that CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis (224), CD146 cross-linking by GAL-1 might play a role in VEGFR-2 signaling (224). Here, GAL is linked to neoplasm.