Ether-a-go-go (EAG) channels, also known as Kv10.1 and KCNH1 channels, contribute to the regulation of neuronal excitability (1, 2, 3) and gain-of-function genetic mutations in EAG channels are associated with severe neurological disorders (4, 5, 6, 7, 8). Here, KCNH1 is linked to nervous system disorder.