GNRH1 and polycystic ovary syndrome: In addition, although we showed that we can efficiently target and modulate 50–60% of septal and hypothalamic GnRH neurons using our Cre-dependent chemogenetic strategy, which is sufficient to drive PCOS-like neuroendocrine traits, we cannot rule out the possibility that downstream neuronal targets of GnRH neurons may be also activated upon the chemogenetic protocol.