Clinical studies report that most PCOS patients exhibit higher luteinizing hormone (LH) pulsatile secretion, which hints at central alterations affecting gonadotropin-releasing hormone (GnRH) neurons10, 11, 12, 13, 14, 15, 16, 17, 18, 19 and recent investigations performed by us also highlighted the brain’s role in the neuroendocrine dysfunction of PCOS both in rodents and humans.20 This evidence concerns the gene PLOD1 and polycystic ovary syndrome.