,23 Reflecting back on PCOS, nearly 70–75% of these patients present increased LH pulse frequency, regardless of their body mass index (BMI) and more than 90% of PCOS patients have a persistently high LH to FSH ratio,11,24, 25, 26 which suggests the presence of an increased GnRH pulse frequency in women with PCOS. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.