,23 Reflecting back on PCOS, nearly 70–75% of these patients present increased LH pulse frequency, regardless of their body mass index (BMI) and more than 90% of PCOS patients have a persistently high LH to FSH ratio,11,24, 25, 26 which suggests the presence of an increased GnRH pulse frequency in women with PCOS. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.