Specific novel findings include the investigation of the causal role of plasma adiponectin in aortic valve stenosis and the use of individual participant data in Mendelian randomization facilitating exploration of subgroup associations and non-linear effects in the risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction. The gene discussed is ADIPOQ; the disease is myocardial infarction.