Results were similar in a less adjusted model by excluding factors that have previously been shown to eliminate the U-shaped association at lower plasma adiponectin concentrations,35,36 that is, diabetes, use of lipid-lowering drugs, non-HDL cholesterol, and plasma high-sensitive C-reactive protein (compare Figures 2–3 with Supplementary material online, Figures S2 and S3). This evidence concerns the gene ADIPOQ and diabetes mellitus.