In genetic one-sample Mendelian randomization analyses using the Wald-type estimator, a 1 μg/mL higher plasma adiponectin was associated with a causal risk ratio of 1.00 (95% CI: 0.98–1.02) for heart failure (Figure 5, lower part), 0.99 (0.98–1.01) for atrial fibrillation (see Supplementary material online, Figure S10, lower part), 1.03 (0.99–1.07) for aortic valve stenosis (see Supplementary material online, Figure S11, lower part), and 0.99 (0.97–1.02) for myocardial infarction (see Supplementary material online, Figure S12, lower part). Here, ADIPOQ is linked to heart failure.