ADIPOQ and stricture: For two-sample Mendelian randomization analyses data are available through the MR-Base platform using GWAS Catalog27 or from the UKB.26 In the present study, we used data on plasma adiponectin (ADIPOGen id:ieu-a-1), heart failure (HERMES id:ebi-a-GCST009541), and atrial fibrillation (AFGen id:ebi-a-GCST006414) from the MR-Base platform,27 and aortic valve stenosis and myocardial infarction from the UKB.26