In contrast, in observational analyses a 1 μg/mL higher plasma adiponectin was associated with a hazard ratio of 1.02 (95% CI: 1.02–1.03) for heart failure (Figure 5, upper part), 1.02 (1.02–1.03) for atrial fibrillation (see Supplementary material online, Figure S10, upper part), 1.01 (1.00–1.02) for aortic valve stenosis (see Supplementary material online, Figure S11, upper part), and 1.01 (1.00–1.01) for myocardial infarction (see Supplementary material online, Figure S12, upper part). The gene discussed is ADIPOQ; the disease is heart failure.