HMGB1 and lip and oral cavity carcinoma: Furthermore, the diverse single-nucleotide polymorphisms (SNPs) of HMGB1 are associated with OSCC, and the 1177GG genotype of HMGB1 is correlated with lymphatic metastasis and tumor stage in OSCC, suggesting that HMGB1 haplotypes may be relevant to the susceptibility to oral cancer [37].