For instance, ginsenoside can improve the inflammatory microenvironment of cardiomyocytes and enhance the efficiency of the feedforward loop by modulating the HMGB1/NF-κB signaling pathway [65]; in acute kidney injury, quercetin can reduce cell injury and apoptosis by inhibiting HIF-1α in the lncRNA NEAT1/HMGB1 signaling pathway [66]. The gene discussed is HMGB1; the disease is acute kidney injury.