INS and obesity due to melanocortin 4 receptor deficiency: To demonstrate causality, we performedin vivo experiments, showing that D. welbionisJ115T reduced diet-induced obesity and liver weight.The combination of metformin and D. welbionisJ115T did not show additive or synergistic effects.Nevertheless, in accordance with previous studies [19], mice treated with D.welbionis J115T exhibited an improvedglucose profile which we linked to increased glucose-induced insulin secretion.