With respect to tau pathology, 45 had no abnormality (median age, 3rd decade); 12 had rare neurofibrillary tangles and neurites, mainly in the hippocampus and parahippocampal region (median age, 5th decade); 1 had ARTAG; and 2 had AD-NC, one low and one high (7th and 9th decade, respectively) (Supplementary Table 2). This evidence concerns the gene MAPT and Alzheimer disease.