Then, we used the computational predictive system UbiBrowser to verify the characteristics of the E3 ligases interacting with hnRNPA1 and found that Trim21 is an E3 ligase for HNRNPA1, and has been reported to be decreased in GC tissues and its down-regulation was correlated with lower overall survival rate among GC patients[24]. Here, TRIM21 is linked to gastric cancer.