Nevertheless, the transplantation of PVAT from HFD-fed mice on the carotid artery accelerated vascular remodelling after a wire-induced injury in low-density lipoprotein receptor knockout mice.52 These authors have demonstrated that monocyte chemoattractant protein-1 (MCP-1) in PVAT is, at least partly, involved in the PVAT-induced vascular remodelling in obesity. The gene discussed is VLDLR; the disease is obesity due to melanocortin 4 receptor deficiency.