Chemerin, a novel adipokine, has been recently considered a regulator of adipogenesis, inflammation, and a missing link between obesity and vascular dysfunction.23 The gene expression of chemerin was significantly upregulated in the PVAT and mPVAT of A-NOS3 KO NCD mice and A-NOS3 KO HFD mice compared to their respective control mice (Figure 6A and B). This evidence concerns the gene RARRES2 and obesity due to melanocortin 4 receptor deficiency.