Thereafter, a 6-gene signature of AML prognosis was identified, comprising CRLF2, HSP90AA1, MAP2K1, PAFAH1B2, MYCL and SET genes, and using multivariate Cox regression analysis, three genes, MAP2K1, MYCL and PAFAH1B2 were selected for the Transcriptional Score computation. The gene discussed is MAP2K1; the disease is acute myeloid leukemia.