constructed a PA contrast agent based on NIR fluorescence probe ICG and osteopontin antibody (OPN Ab) co‐loaded Ti3C2 nanosheet (OPN Ab/Ti3C2/ICG) to target inflammatory foam cells and distinguish the vulnerable atherosclerosis plaque (Figure 5e).[120] The nanosheet had obvious absorption at 808 nm in a concentration‐dependent manner, and the loading of ICG further enhanced its PA performance (Figure 5f,g). This evidence concerns the gene SPP1 and atherosclerosis.