By screening the public data of young people and patients with osteoporosis, CD47 mRNA expression was increased in osteoporotic human osteoblasts (Figure S2E, Supporting Information), positively correlated with multiple proinflammatory (CD80 and TRAF1) and senescence biomarkers (DNMT3A), and negatively associated with the stemness marker (CARM1) in patients with osteoporosis (Figure S2F, Supporting Information). Here, DNMT3A is linked to osteoporosis.