CGAS and melanoma: For instance, TLR-9, located in the cell endosome, recognizes dsDNA and DNA/RNA hybrids, and cytosolic sensors such as cGAS (cyclic GMP-AMP synthase) and AIM2 (absent in melanoma 2) also detect these molecules, leading to the synthesis of IFN-I and other cytokines [193,194,195,196].