This leads to megakaryocyte activation, biogenesis of activated platelets, and release of thromboxane A2 (TxA2) and PF4 that further activates platelets and their traversal through the cerebral vein sinuses, leading to thromboinflammation, CVST, and thromboembolism in other blood vessels [27,28,29]. This evidence concerns the gene PF4 and Thromboembolism.