And the results showed that the common intersection of these four characteristic gene pathways were homologous recombination, progesterone mediated oocyte maturation, ubiquitin mediated proteolysis, RNA degradation, nucleotide excision repair, systemic lupus erythematosus, oocyte meiosis, intestinal immune network for IgA production, cell cycle, folate biosynthesis, p53 signaling pathway, mismatch repair, vibrio cholerae infection, amino sugar and nucleotide sugar metabolism, and oxidative phosphorylation. The gene discussed is TP53; the disease is systemic lupus erythematosus.