IL1B and neoplasm: Interestingly, we found that HHV-6A altered the tumor microenvironment, dysregulating the production of several pro-inflammatory and pro-oncogenic cytokines by BCPAP cells; indeed, it increased the release of VEGF—that is, a pro-angiogenic, pro-tumorigenic, and immune-suppressive cytokine [27]—and IL-1 beta which, besides inflammation, may sustain carcinogenesis by contributing to angiogenesis, EMT, and shaping the tumor microenvironment into an immunosuppressive one [46].