Future investigations are needed to better understand the mechanisms governing the enhanced ID vRNA generation through the NS1Δ76-86 mutation, explicitly focusing on the interaction of NS1 with the viral replication/transcription complex [71,75,76,77,78] and the potential direct role of IFN in ID vRNA synthesis (e.g., during infection in the presence or absence of IFN stimulation). The gene discussed is IFNA1; the disease is infection.