Such indicators as male sex, ACE2 rs2074192 allele T, IFNAR2 rs2236757 allele A, OAS1 rs10774671 allele A, CD40 rs4813003 allele C and CASP3 rs113420705 allele C can predict severe COVID-19 course and MIS-C in the pediatric population in 85.6% of cases (Table 15). This evidence concerns the gene ACE2 and COVID-19.