The frequency of ACE2 rs2074192, IFNAR2 rs2236757, OAS3 rs10735079, FCGR2A rs1801274 and CASP3 rs113420705 genotypes did not follow the Hardy–Weinberg equilibrium (p < 0.05) due to the directional selection made in our study (focusing on patients with COVID-19). This evidence concerns the gene ACE2 and COVID-19.